Anyone work in multiple States?

Im in SC and Savannah,GA is like 30 min. from me. Debating on going down there to setup a route. Its the nearst city to me. Is it a pain to deal with the paper work and taxes to work in multiple states? I’m still a small business. There are plenty on stores there.

We work in 3 states… we just happen to be on the boarder of all of them. So we kinda have to. It is a pain to set up at first, but it gets easier. Basically the main issue is 3 different sales tax rates paid on 3 different schedules.

Va, tn

MD & PA but I don’t do enough work in PA to worry about sales tax yet, probably next year I’ll set that up.